Saquinavir

saquinavir
IUPAC name: see Chemistry section Synonyms: SVQ Formula: C38H50N6O5
Uses:	HIV
Properties:	protease inhibitor
Hazards:	see drug interactions
Mass (g/mol): CAS #: 670.8408 127779-20-8

Saquinavir, abbreviated SQV and sold under the trade names Fortovase®, Invirase® and ROC®, is a protease inhibitor used to treate HIV/AIDS. It is effective againsts HIV-1 and HIV-2. Saquinavir binds to the protease active site and inhibits its activity, thus preventing cleavage of the viral polyproteins resulting in immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs and due to their short half-life, often must be taken about every four hours.

Chemistry

Its IUPAC chemical name is (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide and its chemical formula is C₃₈H₅0N₆O₅.

External links

• Saquinavir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Template:MedMaster
• Template:DrugBank